A distinct transition from cell growth to physiological homeostasis in the tendon

Mor Grinstein, Heather L Dingwall, Luke D O’Connor, Ken Zou, Terence Dante Capellini, Jenna Lauren Galloway

eLife 8:e48689 (2019) DOI: 10.7554/eLife.48689

November 2019

Changes in cell proliferation define transitions from tissue growth to physiological homeostasis. In tendons, a highly organized extracellular matrix undergoes significant postnatal expansion to drive growth, but once formed, it appears to undergo little turnover. However, tendon cell activity during growth and homeostatic maintenance is less well defined. Using complementary methods of genetic H2B-GFP pulse-chase labeling and BrdU incorporation in mice, we show significant postnatal tendon cell proliferation, correlating with longitudinal Achilles tendon growth. Around day 21, there is a transition in cell turnover with a significant decline in proliferation. After this time, we find low amounts of homeostatic tendon cell proliferation from 3 to 20 months. These results demonstrate that tendons harbor significant postnatal mitotic activity, and limited, but detectable activity in adult and aged stages. It also points towards the possibility that the adult tendon harbors resident tendon progenitor populations, which would have important therapeutic implications.

Full text of Dr M. Grinstein’s  article is available from HERE

Mor Grinstein 
First Author

Harvard University, USA.

Ronald ‘Ron’ Kwon

University of Washington, USA.