MY MENTOR & I PERSPECTIVE
Multiple myeloma and fatty acid metabolism
Assistant Professor Michaela Reagan is head of the MMCRI Reagan Laboratory, which focuses on myeloma and diseases of the bone and bone marrow. Her research examines how the bone marrow niche supports myeloma colonization, proliferation, and drug resistance. To do this, she has focused her research on the cells that make up the stroma of the bone marrow, such as the bone marrow adipocyte, which she has found play an important role in bidirectional signaling with myeloma cells. Her current research goal is to help the scientific community better understand the biology of the bone marrow adipocyte and its interactions with myeloma cells, with the overall aim of creating better therapies for myeloma patients and patients with other bone diseases.
Dr Majdi Masarwi is a post-doctoral fellow in the Reagan Laboratory at the Maine Medical Center Research Institute (MMCRI). His research project aims to understand the role of fatty acids and lipid metabolism in promoting multiple myeloma cells growth and how bone marrow adipocytes promote to tumor progression and drug resistance.